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The agency also announced Thursday that it will impose new restrictions on the sales of flavored e-cigarettes in retail stores, limiting them to closed-off areas that are inaccessible to minors

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Aside from these confounders, because the absolute risk of the development of SLE is very small in the general population, cohorts with very large numbers of patients and healthy subjects are required to address the relationship between cigarette smoking and the risk of development of SLE

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